HOW IT WORKS

quotes Learning more about B-cell treatments and how KESIMPTA® was precisely delivered made me feel
more comfortable getting started. quotes

WALT D.

Started on KESIMPTA in 2021

Walt D. has taken KESIMPTA and has been compensated for his time.
Individual results may vary.


How KESIMPTA Works

KESIMPTA is the only B-cell treatment for RMS that's delivered as a once-monthly* at-home injection.

*Once monthly after 3 weekly starter doses.

WHAT HAPPENS IN RMS

To understand how KESIMPTA works, it's important to know how B-cells and relapsing MS are connected.

b-cell-women

For illustrative purposes only.

B-cells

B-cells are a part of the immune system that help fight infections. They are found throughout the body.

RMS-related B-cells

In RMS, immune cells, such as B-cells, located in the lymph nodes, are mistakenly sent to attack the body's myelin—the protective covering around the nerves in the brain and spinal cord.

For illustrative purposes only.

WHAT HAPPENS IN RMS

To understand how KESIMPTA works, it's important to know how B-cells and relapsing MS are connected.

b-cell-women

For illustrative purposes only.

b cell

B-cells

B-cells are a part of the immune system that help fight infections. They are found throughout the body.

bcell pentagon bcell pentagon

RMS-related B-cells

In RMS, immune cells, such as B-cells, located in the lymph nodes, are mistakenly sent to attack the body's myelin—the protective covering around the nerves in the brain and spinal cord.

For illustrative purposes only.

KESIMPTA IS PRECISELY DELIVERED

While it's not fully understood how KESIMPTA works, it's designed to target the B-cells† in the lymph nodes believed to play a role in RMS.

pentagon-injection

For illustrative purposes only.

b cell

B-cells

bcell pentagon

RMS-related B-cells

  • Think of your body as a maze with many possible paths

  • As a subcutaneous injection just under the skin,
    KESIMPTA is thought to target a precise path to
    RMS-related B-cells†

†Based on preclinical studies.

Targeted delivery with the KESIMPTA Sensoready® Pen to the lymph nodes is thought to
limit the impact on other B-cells your body needs to maintain immune function.

Jennifer image

quotes As a biochemist, I was excited about the only at-home, B-cell RMS therapy with subcutaneous delivery. quotes

– SEAN C.

Sean C. has taken KESIMPTA and has been compensated for his time.
Individual results may vary.

Jennifer image

quotes As a biochemist, I was excited about the only at-home, B-cell RMS therapy with subcutaneous delivery. quotes

– SEAN C.

Sean C. has taken KESIMPTA and has been compensated for his time.
Individual results may vary.

Check out how to take
KESIMPTA.

LEARN MORE HERE

Check out the safety
profile.

GET THE DETAILS
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Looking for help navigating
life with RMS?

Let us bring you
personalized resources.

Sign Up

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Pay as little as $0 co-pay‡ & enroll in the
Alongside™ KESIMPTA Support Program.

Learn More

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Pay as little as $0 co-pay‡ &
enroll in the Alongside™
KESIMPTA Support Program.

Learn More

MS, multiple sclerosis; RMS, relapsing multiple sclerosis.

‡Limitations apply. Offer not valid under Medicare, Medicaid, or any other federal or state health insurance program. Patients with commercial insurance coverage for KESIMPTA may receive up to $18,000 in annual co-pay benefits. Patients with commercial insurance and an initial denial of coverage may receive up to 12 months of free product while coverage is pursued. Novartis reserves the right to rescind, revoke, or amend this program without notice. See complete Terms & Conditions at start.kesimpta.com.

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IMPORTANT SAFETY INFORMATION

Who should not take KESIMPTA?

Do NOT take KESIMPTA if you:

  • have an active hepatitis B virus (HBV) infection.

  • have had an allergic reaction to ofatumumab or life-threatening

INDICATION

What is KESIMPTA (ofatumumab) injection?

KESIMPTA is a prescription medicine used to treat adults with relapsing forms of multiple sclerosis (MS)

KESIMPTA is a prescription medicine used to treat adults with relapsing forms of multiple

IMPORTANT SAFETY INFORMATION & INDICATION

INDICATION

What is KESIMPTA (ofatumumab) injection?

KESIMPTA is a prescription medicine used to treat adults with relapsing forms of multiple sclerosis (MS) including clinically isolated syndrome (CIS), relapsing-remitting disease, and active secondary progressive disease.

It is not known if KESIMPTA is safe or effective in children.

IMPORTANT SAFETY INFORMATION

Who should not take KESIMPTA?

Do NOT take KESIMPTA if you:

  • have an active hepatitis B virus (HBV) infection.

  • have had an allergic reaction to ofatumumab or life-threatening injection-related reaction to KESIMPTA.

What is the most important information I should know about KESIMPTA?

KESIMPTA can cause serious side effects such as:

  • Infections. Serious infections, which can be life-threatening or cause death, can happen during treatment with KESIMPTA. If you have an active infection, your health care provider (HCP) should delay your treatment with KESIMPTA until your infection is gone. KESIMPTA taken before or after other medicines that weaken the immune system may increase your risk of getting infections. Tell your HCP right away if you have any infections or get any symptoms including painful and frequent urination, nasal congestion, runny nose, sore throat, fever, chills, cough, or body aches.

INDICATION

What is KESIMPTA (ofatumumab) injection?

KESIMPTA is a prescription medicine used to treat adults with relapsing forms of multiple sclerosis (MS) including clinically isolated syndrome (CIS), relapsing-remitting disease, and active secondary progressive disease.

It is not known if KESIMPTA is safe or effective in children.

  • HBV reactivation. If you have ever had HBV infection, it may become active again during or after treatment with KESIMPTA (reactivation). If this happens, it may cause serious liver problems including liver failure or death. Before starting KESIMPTA, your HCP will do a blood test to check for HBV. They will also continue to monitor you during and after treatment with KESIMPTA for HBV. Tell your HCP right away if you get worsening tiredness or yellowing of your skin or the white part of your eyes.

  • Progressive Multifocal Leukoencephalopathy (PML). PML may happen with KESIMPTA. PML is a rare, serious brain infection caused by a virus that may get worse over days or weeks. PML can result in death or severe disability. Tell your HCP right away if you have any new or worsening neurologic signs or symptoms. These may include weakness on one side of your body, loss of coordination in arms and legs, vision problems, changes in thinking and memory, which may lead to confusion and personality changes.

  • Weakened immune system. KESIMPTA taken before or after other medicines that weaken the immune system could increase your risk of getting infections.

Before you take KESIMPTA, tell your HCP about all your medical conditions, including if you:

  • Have or think you have an infection including HBV or PML.

  • Have ever taken, currently take, or plan to take medicines that affect your immune system. These medicines could increase your risk of getting an infection.

  • Have had a recent vaccination or are scheduled to receive any vaccinations.

    • You should receive any required 'live' or 'live-attenuated' vaccines at least 4 weeks before you start treatment with KESIMPTA. You should not receive 'live' or 'live-attenuated' vaccines while you are being treated with KESIMPTA and until your HCP tells you that your immune system is no longer weakened.

    • Whenever possible, you should receive any 'non-live' vaccines at least 2 weeks before you start treatment with KESIMPTA.

    • Talk to your HCP about vaccinations for your baby if you used KESIMPTA during your pregnancy.

  • Are pregnant, think that you might be pregnant, or plan to become pregnant. It is not known if KESIMPTA will harm your unborn baby. Females who can become pregnant should use birth control (contraception) during treatment with KESIMPTA and for 6 months after your last treatment. Talk with your HCP about what birth control method is right for you during this time.

  • Are breastfeeding or plan to breastfeed. It is not known if KESIMPTA passes into your breast milk. Talk to your HCP about the best way to feed your baby if you take KESIMPTA.

Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How should I use KESIMPTA?

See the detailed Instructions for Use that comes with KESIMPTA for information about how to prepare and inject a dose of KESIMPTA and how to properly throw away (dispose of) used KESIMPTA Sensoready pens or prefilled syringes.

  • Use KESIMPTA exactly as your HCP tells you to use it.

  • Your HCP will show you how to prepare and inject KESIMPTA the right way before you use it for the first time.

  • Do not inject into areas where the skin is tender, bruised, red, scaly or hard. Avoid areas with moles, scars, or stretch marks.

KESIMPTA may cause serious side effects including:

  • Injection-related reactions. Injection-related reactions are a common side effect of KESIMPTA. Injecting KESIMPTA can cause injection-related reactions that can happen within 24 hours (1 day) following the first injections and with later injections. There are two kinds of reactions:

    • at or near the injection site: redness of the skin, swelling, itching, and pain. Talk to your HCP if you have any of these signs and symptoms.

    • that may happen when certain substances are released in your body: fever, headache, pain in the muscles, chills, tiredness, rash, hives, trouble breathing, swelling of the face, eyelids, lips, mouth, tongue and throat, and feeling faint, or chest tightness. Contact your HCP right away if you experience any of these signs and symptoms, especially if they become worse or you have new severe signs of reactions after subsequent injections. It could be a sign of an allergic reaction, which can be serious.

  • Low immunoglobulins. KESIMPTA may cause a decrease in some types of antibodies. Your HCP will do blood tests to check your blood immunoglobulin levels.

The most common side effects of KESIMPTA include:

  • Upper respiratory tract infection, with symptoms such as sore throat and runny nose, and headache.

  • Headache.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information including Medication Guide.

KESIMPTA, the KESIMPTA logo, and SENSOREADY are registered trademarks of Novartis AG.

ALONGSIDE and the ALONGSIDE logo are trademarks of Novartis AG.

AUBAGIO is a registered trademark of Genzyme, a Sanofi company.

Please see each product's respective PI for additional information including indication, dosing, and safety.